INTRODUCTION
A potent b-blocker with prominent intrinsic sympathomimetic
activity. It has been used primarily as hypertensive may be adv in patient who
develop marked bradycardia with propranolol
PHARMACOKINETIC
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Moderate lipid solubility
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Halflife:3-4hrs
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Bioavailability:90%
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MECHANISM OF ACTION
Pindolol non selectively blocks beta-1 adrenergic receptor
mainly in the heart inhibiting the effect of epinephrine and norepinephrine
resulting in a decrease in heart rate and blood pressure by binding beta-2
receptor.pindolol inhibit the production of renin thereby inhibiting
angiotensin-II and aldosterone production and therefore inhibit the
vasoconstriction and water retention due to angiotensin-II and aldosterone respectively
USES
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Hypertension
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Angina pectoris
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Cardiac arrhythmias
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MI
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Congestive heart failure
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Pheochromocytoma
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Migraine
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Anxiety
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Glaucoma
ADVERSE EFFECT
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Beta blocker can worsen asthma and heart failure
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Produce hypoglycemia
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CNS disturbance
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Lethargy and vivid nightmares
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DOSE
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ORAL: (5-15)mg tab
Some marketed brand
INADOL 5mg VIKEN 10,15mg
